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KMID : 0606920080160040416
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Biomolecules & Therapeutics
2008 Volume.16 No. 4 p.416 ~ p.424
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Antihistamine Activities of Iminodiacetamide Derivatives
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Rhee Soo-Jin
Kam Yoo-Lim
Seo Young-Hee
ParkChoo Hea-Young
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Abstract
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A series of N,N’-substituted iminodiacetamide derivatives was synthesized and evaluated their inhibitory effects on the histamine-induced smooth muscle contraction in guinea-pig ileum and on the histamine release from IgE-sensitized RBL-2H3 cells (rat basophilic leukemia cell line). Compounds A3, A4 and A5 which have 1-(4-chlorobenzhydryl) piperazine moiety, showed both moderate antihistamine activity and histamine release inhibitory activity.
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KEYWORD
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Iminodiacetamide, Allergy, Antihistamine, Guinea-pig ileum, Histamine release, RBL-2H3
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